![](\"http:\/\/www.erzurumflas.com\/wp-content\/uploads\/2015\/11\/ilac-arastirmalarinda-esit-temsil-saglanmali_aec1710.jpg\")
\u0130la\u00e7 ara\u015ft\u0131rmalar\u0131nda her iki cinsin e\u015fit yer almas\u0131 gerekti\u011fi yakla\u015f\u0131k 25 y\u0131ld\u0131r vurgulan\u0131yor. Prof. Dr. G\u00fcla\u00e7t\u0131 Top\u00e7u, ila\u00e7lar\u0131n etkisinin anla\u015f\u0131lmas\u0131n\u0131n ila\u00e7 \u015firketlerinin kozmopolit bir ara\u015ft\u0131rma y\u00fcr\u00fctmesiyle m\u00fcmk\u00fcn olabilece\u011fini ifade etti.<\/p>\n
\u0130la\u00e7lar\u0131n piyasaya \u00e7\u0131kmadan \u00f6nce ge\u00e7irdi\u011fi a\u015famalar\u0131 aktaran Bezmialem Vak\u0131f \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Dekan\u0131 Prof. Dr. G\u00fcla\u00e7t\u0131 Top\u00e7u, cinsiyet, beslenme bi\u00e7imi, iklim gibi etkilerin de ila\u00e7 ara\u015ft\u0131rmalar\u0131nda \u00f6nem arz etti\u011fini ifade etti. Top\u00e7u, ilac\u0131n piyasaya \u00e7\u0131kmadan \u00f6nce \u00e7ok \u00e7e\u015fitlilikte ara\u015ft\u0131rma imk\u00e2n\u0131na ila\u00e7 firmas\u0131n\u0131n kozmopolit bir yerde ara\u015ft\u0131rmalar\u0131n\u0131 y\u00fcr\u00fctmesiyle eri\u015febilece\u011fini ekledi.<\/p>\n
\u0130LA\u00c7LARIN C\u0130NS\u0130YETE BA\u011eLI ETK\u0130LER\u0130<\/p>\n
Pek \u00e7ok ila\u00e7ta kad\u0131n ve erke\u011fe g\u00f6re farkl\u0131l\u0131k g\u00f6steren durumlar olu\u015ftu\u011funu s\u00f6yleyen Prof. Dr. G\u00fcla\u00e7t\u0131 Top\u00e7u, bu nedenle ara\u015ft\u0131rmalar\u0131n her iki cinste yap\u0131lmas\u0131 \u015fart oldu\u011funu ancak bazen ihmal edilen durumlar olabildi\u011fini ekledi:<\/p>\n
\u201c1990 y\u0131l\u0131nda ABD Ulusal Sa\u011fl\u0131k Enstit\u00fcs\u00fc\u2019n\u00fcn (National Institutes of Health-NIH) ikincil cinsiyet olarak g\u00f6r\u00fclen kad\u0131nlar\u0131n ila\u00e7 deneylerinde e\u015fit olarak yer almas\u0131na dikkat etmeye ba\u015flad\u0131. ABD Ulusal Sa\u011fl\u0131k Enstit\u00fcs\u00fc bu konuda \u00e7e\u015fitli \u00e7al\u0131\u015fmalar yapt\u0131rd\u0131. B\u00fct\u00fcn d\u00fcnyada buna daha imtina g\u00f6sterilmeye \u00e7al\u0131\u015f\u0131l\u0131yor. Bunun uygulanmamas\u0131nda bir di\u011fer fakt\u00f6r de kad\u0131nlar\u0131n buna s\u0131cak bakmamas\u0131 olabilir\u201d.<\/p>\n
KADINLAR KALP RAHATSIZLI\u011eINDA R\u0130SK ALTINDA<\/p>\n
\u0130la\u00e7lar\u0131n cinsiyete ba\u011fl\u0131 farkl\u0131 etkilerinin g\u00f6r\u00fcld\u00fc\u011f\u00fc rahats\u0131zlardan biri olarak kalp rahats\u0131zl\u0131klar\u0131ndan s\u00f6z eden Prof. Dr. Top\u00e7u, erkeklerin daha \u00e7ok kalp rahats\u0131zl\u0131\u011f\u0131 ge\u00e7irdi\u011fi iddialar\u0131na ili\u015fkin kad\u0131nlar\u0131n da ayn\u0131 \u015fekilde risk alt\u0131nda oldu\u011funu s\u00f6yledi. Top\u00e7u, stres \u00e7a\u011f\u0131 ya\u015fand\u0131\u011f\u0131n\u0131 s\u00f6yledi ve kad\u0131nlar\u0131n bu ortamdaki stres y\u00fck\u00fcn\u00fc vurgulad\u0131:<\/p>\n
\u201cKad\u0131nlar bir \u00e7ok rol\u00fc ayn\u0131 anda ger\u00e7ekle\u015ftirmeye \u00e7al\u0131\u015f\u0131yor, hem ba\u015far\u0131l\u0131 bir i\u015f kad\u0131n\u0131 hem de iyi bir anne olmaya \u00e7al\u0131\u015f\u0131yor, bir de b\u00fcy\u00fck \u015fehirde ya\u015f\u0131yorsa b\u00fcy\u00fck bir stres alt\u0131nda kal\u0131yor. Kalp rahats\u0131zl\u0131klar\u0131nda genetik fakt\u00f6rlerin ve beslenme bi\u00e7imlerinin etkisiyle birlikte risk almak ve stres ya\u015famak da \u00f6nemli bir fakt\u00f6r. Bu ya\u015fam ko\u015fullar\u0131nda kad\u0131nlar kalp rahats\u0131zl\u0131\u011f\u0131nda risk alt\u0131ndalar, bu nedenle erkekler kadar ara\u015ft\u0131r\u0131lmalar\u0131, denek olarak kullan\u0131lmalar\u0131 gerekir\u201d.<\/p>\n
B\u0130R \u0130LA\u00c7 P\u0130YASAYA \u00c7IKARKEN HANG\u0130 A\u015eAMALARDAN GE\u00c7\u0130YOR?<\/p>\n
Klinik ara\u015ft\u0131rmalar\u0131 kapsayan ilk a\u015fama faz 1\u2019i anlatan Prof. Dr. G\u00fcla\u00e7t\u0131 Top\u00e7u,<\/p>\n
\u201c\u0130la\u00e7 sekt\u00f6r\u00fcnde sentetik bir ila\u00e7 piyasaya s\u00fcr\u00fclmeden \u00f6nce faz 1 ara\u015ft\u0131rmalar\u0131 yap\u0131l\u0131r. ADME (Absorbsiyon, da\u011f\u0131l\u0131m, metabolizma, eliminasyon) olarak k\u0131salt\u0131lan a\u015famalardan ge\u00e7er. Ayr\u0131ca d\u0131\u015far\u0131 at\u0131lma ve toksikolojik ara\u015ft\u0131rmalardan olu\u015fur. Bu ara\u015ft\u0131rmalar hayvanlar \u00fczerinde hatta hayvanlar \u00fczerindeki deneylerden \u00f6nce de in vitro yani h\u00fccre k\u00fclt\u00fcr\u00fc ortam\u0131nda ve steril \u015fartlarda yap\u0131l\u0131yor\u201d dedi.<\/p>\n
Di\u011fer a\u015famalar hakk\u0131nda bilgi veren Prof. Dr. Top\u00e7u, \u201cPreklinik ara\u015ft\u0131rmalar dedi\u011fimiz hayvanlar\u0131 da kapsayan bu ara\u015ft\u0131rmalardan sonra Faz 2\u2019ye ge\u00e7iliyor. Faz 2\u2019de belli say\u0131da 100-300 kadar sa\u011fl\u0131kl\u0131 ve g\u00f6n\u00fcll\u00fc insanlar \u00fczerinde deneniyor. Piyasaya \u00e7\u0131kan ila\u00e7 sa\u011fl\u0131kl\u0131 insana zarar veriyor mu, buna bak\u0131l\u0131yor. Faz 3\u2019te ise ger\u00e7ekten hasta \u00fczerinde deneniyor, \u00f6rne\u011fin \u00fclseri olan hasta anti \u00fclser bir ilac\u0131 kullan\u0131yor. Faz 3\u2019te denek say\u0131s\u0131 daha fazla oluyor ve bu a\u015famadan sonra ila\u00e7 piyasaya \u00e7\u0131k\u0131yor.<\/p>\n
Piyasaya \u00e7\u0131kt\u0131ktan sonra yap\u0131lan ara\u015ft\u0131rmalar ise Faz 4\u2019\u00fc kaps\u0131yor. Farkl\u0131 b\u00fcy\u00fck kitlelere eri\u015fiyor, ilac\u0131n toksik ve ya yan tesirleri daha \u00e7ok anla\u015f\u0131l\u0131yor\u201d diye konu\u015ftu.<\/p>\n
Top\u00e7u, ara\u015ft\u0131rmalar\u0131n etik boyuta de\u011findi: \u201cAra\u015ft\u0131rmalar\u0131n hepsinde ki\u015filerin r\u0131zas\u0131 al\u0131nmal\u0131, belli protokoller \u00e7er\u00e7evesinde bu yap\u0131lmal\u0131\u201d ifadelerini kulland\u0131.<\/p>\n
ARA\u015eTIRMALARDA \u00c7E\u015e\u0130TL\u0130L\u0130K<\/p>\n
Bir ilac\u0131n etkisinin ara\u015ft\u0131r\u0131l\u0131rken sa\u011fl\u0131kl\u0131 g\u00f6n\u00fcll\u00fclerden ba\u015fland\u0131\u011f\u0131 Faz 2\u2019den itibaren ara\u015ft\u0131rmalar\u0131n \u00e7e\u015fitli ve farkl\u0131 bireyler \u00fczerinde denenmesinin olumlu sonu\u00e7lar olu\u015fturaca\u011f\u0131n\u0131 belirten G\u00fcla\u00e7t\u0131 Top\u00e7u, \u201c\u00d6rne\u011fin, yeti\u015fkinler i\u00e7in \u00e7\u0131km\u0131\u015f ila\u00e7larda \u00f6zellikle yeti\u015fkinlerde denenmeli ve \u00f6zellikle de her iki cins \u00fczerinde de ara\u015ft\u0131rma yap\u0131lmal\u0131, hatta farkl\u0131 \u0131rk insanlar\u0131 \u00fczerinde de yap\u0131lmal\u0131. Farkl\u0131 iklimlerde ya\u015fayan, farkl\u0131 beslenme bi\u00e7imlerine sahip olan insanlar\u0131 kapsasa daha iyi olur. Ancak bunu ilk a\u015famalarda Faz 2 ve Faz 3\u2019te ger\u00e7ekle\u015ftirmek i\u00e7in ara\u015ft\u0131rmalar\u0131n kozmopolit bir yap\u0131ya sahip bir \u00fclkede y\u00fcr\u00fct\u00fclmesi gerekir\u201d dedi.<\/p>\n","protected":false},"excerpt":{"rendered":"
PROF. DR. G\u00dcLA\u00c7TI TOP\u00c7U, \u0130LA\u00c7LARIN P\u0130YASA \u00c7IKMA S\u00dcREC\u0130N\u0130 ANLATIYOR, \u0130LA\u00c7 DENEYLER\u0130NDE C\u0130NS\u0130YETE BA\u011eLI ETK\u0130LER\u0130N G\u00d6Z \u00d6N\u00dcNDE TUTULMASI VE \u00c7OK \u00c7E\u015e\u0130TL\u0130 FAKT\u00d6RLER\u0130N DE BUNA DAH\u0130L ED\u0130LMES\u0130N\u0130N OLUMLU ETK\u0130LER\u0130NDEN S\u00d6Z ED\u0130YOR.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,20],"tags":[23516,23517,2171,23518,13129],"class_list":["post-129414","post","type-post","status-publish","format-standard","hentry","category-saglik","category-turkiye","tag-arastirmalarinda","tag-esit","tag-ilac","tag-saglanmali","tag-temsil"],"_links":{"self":[{"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/129414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=129414"}],"version-history":[{"count":0,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/129414\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=129414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=129414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=129414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}