{"id":1544369,"date":"2020-11-03T00:04:05","date_gmt":"2020-11-02T21:04:05","guid":{"rendered":"http:\/\/www.erzurumflas.com\/teknolojide-losemi-sag-kalim-oranini-arttiriyor\/"},"modified":"2020-11-03T00:04:08","modified_gmt":"2020-11-02T21:04:08","slug":"teknolojide-losemi-sag-kalim-oranini-arttiriyor","status":"publish","type":"post","link":"https:\/\/www.erzhaber.com.tr\/?p=1544369","title":{"rendered":"Teknolojide l\u00f6semi sa\u011f kal\u0131m oran\u0131n\u0131 artt\u0131r\u0131yor"},"content":{"rendered":"

Medical Park Gaziantep Hastanesi \u00c7ocuk Hematolojisi Uzman\u0131 Do\u00e7. Dr. Mesut Garipard\u0131\u00e7, 2-8 Kas\u0131m L\u00f6semili \u00c7ocuklar Haftas\u0131\u2019nda hastal\u0131\u011f\u0131n en \u00e7ok 2 ile 5 ya\u015f aras\u0131ndaki erkek \u00e7ocuklarda s\u0131kl\u0131kla g\u00f6r\u00fcld\u00fc\u011f\u00fcne dikkat \u00e7ekerek, tedavi yakla\u015f\u0131mlar\u0131n\u0131n ve teknolojideki ilerlemeler sayesinde sa\u011f kal\u0131m oranlar\u0131 ve hastan\u0131n ya\u015fam kalitesi artt\u0131\u011f\u0131n\u0131 ifade etti.<\/p>\n

Medical Park Gaziantep Hastanesi \u00c7ocuk Hematolojisi Uzman\u0131 Do\u00e7. Dr. Mesut Garipard\u0131\u00e7, 2-8 Kas\u0131m L\u00f6semili \u00c7ocuklar Haftas\u0131 hakk\u0131nda \u2018\u2019\u00c7ocukluk \u00c7a\u011f\u0131nda L\u00f6semi\u2019\u2019 hastal\u0131\u011f\u0131na dikkat \u00e7ekmek ve fark\u0131ndal\u0131k olu\u015fturmak i\u00e7in bilgilendirmelerde bulundu. Akut lenfoblastik l\u00f6semi \u00e7ocukluk \u00e7a\u011f\u0131nda ilk defa 1827 y\u0131l\u0131nda, ate\u015f, halsizlik ve yayg\u0131n kemik a\u011fr\u0131s\u0131 \u015fikayeti olan bir hastada tan\u0131mland\u0131\u011f\u0131n\u0131n alt\u0131n\u0131 \u00e7izen Mesut Garipard\u0131\u00e7, \u201cVirhow isimli bir ara\u015ft\u0131rmac\u0131 taraf\u0131ndan ise 1847\u2019de bu hastal\u0131\u011fa \u2018\u2019Beyaz Kan \u2018\u2019 manas\u0131na gelen L\u00f6semi ad\u0131 verilmi\u015ftir. 1891 y\u0131l\u0131 sonras\u0131nda ise Ehrlich isimli ara\u015ft\u0131rmac\u0131 taraf\u0131ndan, boyama y\u00f6ntemleri ile l\u00f6semik h\u00fccreler boyanm\u0131\u015f bu \u015fekilde l\u00f6semi alt tipleri anla\u015f\u0131lmaya ba\u015flanm\u0131\u015ft\u0131r. Daha sonraki d\u00f6nemlerde ise l\u00f6semi, akut veya kronik, lenfoid veya myloid olarak s\u0131n\u0131flanm\u0131\u015ft\u0131r. \u00c7ocuklardaki l\u00f6semi biyolojisinin detayl\u0131 anla\u015f\u0131lmas\u0131 sonucunda, hastal\u0131k, klinik, genetik ve imm\u00fcnolojik olarak farkl\u0131 alt hastal\u0131k gruplar\u0131n\u0131 tan\u0131mlayan geni\u015f bir terimdir. Bu sayede ayn\u0131 hastal\u0131\u011f\u0131n farkl\u0131 risk gruplar\u0131na g\u00f6re farkl\u0131 tedavi se\u00e7enekleri de geli\u015fmektedir\u201d dedi.<\/p>\n

2-5 ya\u015f aras\u0131ndaki erkek \u00e7ocuklarda s\u0131kl\u0131kla g\u00f6r\u00fclmektedir<\/p>\n

Medical Park Gaziantep Hastanesi \u00c7ocuk Hematolojisi Uzman\u0131 Do\u00e7. Dr. Garipard\u0131\u00e7, L\u00f6semilerin en s\u0131k g\u00f6r\u00fclen bi\u00e7iminin akut lenfoblastik l\u00f6semi oldu\u011funu ve bu rahats\u0131zl\u0131\u011f\u0131n ise 15 ya\u015f\u0131ndan k\u00fc\u00e7\u00fck \u00e7ocuklarda y\u00fcz binde 3 veya 4 oran\u0131na sahip oldu\u011funu kaydetti. L\u00f6seminin en fazla \u00e7ocukluk d\u00f6neminde g\u00f6r\u00fcld\u00fc\u011f\u00fcn\u00fc belirten Do\u00e7. Dr. Garipard\u0131\u00e7, bu hastal\u0131\u011f\u0131n en fazla 2 ile 5 ya\u015f aras\u0131nda g\u00f6r\u00fcld\u00fc\u011f\u00fcn\u00fc ve en fazla erkeklerde meydana geldi\u011fini s\u00f6zlerine ekledi.<\/p>\n

L\u00f6semi niye olu\u015fmaktad\u0131r?<\/p>\n

L\u00f6seminin olu\u015fmas\u0131na neden olan fakt\u00f6rlerin tam olarak bilinemedi\u011fine fakat genetik ve \u00e7evresel fakt\u00f6rlerin etkisinin bilindi\u011fine de\u011finen Garipard\u0131\u00e7, Down Sendromu, Bloom Sendromu, N\u00f6rofibromatozis tip 1 ve Ataksi- Telenjiektazi hastalar\u0131nda l\u00f6semi s\u0131kl\u0131\u011f\u0131n\u0131n artt\u0131\u011f\u0131n\u0131 belirtti. L\u00f6semide en \u00e7ok h\u00fccre \u00e7o\u011falmas\u0131ndan sorumlu genlerin etkilendi\u011fine vurgu yapan Garipard\u0131\u00e7, bu sebeple olgunla\u015fmam\u0131\u015f \u00f6nc\u00fcl h\u00fccreler kontrols\u00fcz olarak \u00e7o\u011falmas\u0131 sebebiyle l\u00f6semiye neden oldu\u011funun alt\u0131n\u0131 \u00e7izerek, \u2018\u2019Yeni do\u011fan d\u00f6neminde bebeklerin topuk kanlar\u0131ndan yap\u0131lan tarama kartlar\u0131nda l\u00f6semiye spesifik f\u00fczyon gen sekanslar\u0131n\u0131n bulunmas\u0131 ve tek yumurta ikizlerinde y\u00fcksek oranda birlikte l\u00f6semi ortaya \u00e7\u0131kmas\u0131, l\u00f6semi olu\u015fumunda genetik fakt\u00f6r\u00fcn etkisini desteklemektedir. L\u00f6semide klinik bulgular, l\u00f6semik h\u00fccrelerin neden oldu\u011fu kemik ili\u011fi yetersizli\u011finin derecesine ve kemik ili\u011fi d\u0131\u015f\u0131 organlar\u0131n etkilenme derecesine g\u00f6re de\u011fi\u015fir. Tan\u0131 konuldu\u011funda, hastal\u0131\u011f\u0131n ilk belirti ve bulgular\u0131 ba\u015flayal\u0131 genellikle birka\u00e7 g\u00fcn veya birka\u00e7 hafta olmu\u015ftur. \u0130lk \u015fikayetler genellikle non spesifiktir, halsizlik, bitkinlik, yorgunluk, kemik a\u011fr\u0131s\u0131 veya i\u015ftahs\u0131zl\u0131k ilk belirtilerdir. Hastalarda spesifik solukluk, kanama ve ate\u015f gibi infeksiyon bulgular\u0131, l\u00f6semik h\u00fccrelerin kemik ili\u011fi i\u015fgal etmesi sonucu olu\u015fur ve bu durum kan yap\u0131m\u0131n\u0131 engeller. Hastan\u0131n hikayesi ve klinik bulgular\u0131 ile l\u00f6semiden \u015f\u00fcphelenildi\u011finde kan say\u0131m\u0131n\u0131n ve \u00f6zellikle periferik kan yaymas\u0131n\u0131n de\u011ferlendirilmesi ile \u00e7o\u011fu vakada h\u0131zl\u0131 tan\u0131 konulur. Bunun yan\u0131nda bu bulgular\u0131n normal olmas\u0131 l\u00f6semiyi d\u0131\u015flamaz ve l\u00f6semi \u015f\u00fcphesi varsa zaman kaybetmeden kemik ili\u011fi aspirasyonu incelemesi ger\u00e7ekle\u015ftirilmelidir. L\u00f6semi ba\u015fka hastal\u0131klarla kar\u0131\u015ft\u0131r\u0131labilir, bu hastal\u0131k romatizmaya bezedi\u011fi i\u00e7in yanl\u0131\u015fl\u0131kla steroidlerle tedavi edilmi\u015ftir. L\u00f6seminin ay\u0131r\u0131c\u0131 tan\u0131s\u0131nda, infeksiyonlar, n\u00f6roblastom gibi kemik ili\u011fini tutan \u00e7ocukluk \u00e7a\u011f\u0131 maligniteleri, kollajen vask\u00fcler hastal\u0131klar, ITP ve aplastik anemi gibi di\u011fer hematolojik hastal\u0131klar yer almaktad\u0131r\u201d ifadelerini kulland\u0131.<\/p>\n

Tedavisi nas\u0131ld\u0131r?<\/p>\n

Medical Park Gaziantep Hastanesi \u00c7ocuk Hematolojisi Uzman\u0131 Do\u00e7. Dr. Garipard\u0131\u00e7 L\u00f6semi tedavisinin g\u00fcn\u00fcm\u00fczde olduk\u00e7a ba\u015far\u0131l\u0131 yap\u0131ld\u0131\u011f\u0131n\u0131 kaydetti. L\u00f6semi tan\u0131s\u0131 konulduktan sonra, hastal\u0131\u011f\u0131n risk grubuna g\u00f6re olu\u015fturulmu\u015f ulusal ve uluslararas\u0131 protokollere g\u00f6re tedavisinin yap\u0131ld\u0131\u011f\u0131n\u0131 aktaran Garipard\u0131\u00e7, \u201cTedavide risk grubuna g\u00f6re \u00e7oklu la\u00e7lar i\u00e7eren kemoterapi baz\u0131 hastalarda MSS\u2019ne y\u00f6nelik radyoterapi \u00f6nerilmektedir. Bunlara ek olarak ise, gerekti\u011finde k\u0131rm\u0131z\u0131 kan (Eritrosit) ve trombosit deste\u011fi, antibiyotikler enteral ve parenteral beslenme \u00fcr\u00fcnleri, a\u011f\u0131z ve cilt bak\u0131m\u0131 gibi destek tedavileri yap\u0131lmaktad\u0131r. Ayr\u0131ca aile i\u00e7i veya aile d\u0131\u015f\u0131ndan uygun vericiden k\u00f6k h\u00fccre tedavisi yap\u0131labilmektedir. Bu sayede tedavi yakla\u015f\u0131mlar\u0131 ve teknolojideki ilerlemeler sa\u011f kal\u0131m oranlar\u0131 ve hastan\u0131n ya\u015fam kalitesi art\u0131rmaktad\u0131r\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"

MED\u0130CAL PARK GAZ\u0130ANTEP HASTANES\u0130 \u00c7OCUK HEMATOLOJ\u0130S\u0130 UZMANI DO\u00c7. DR. MESUT GAR\u0130PARDI\u00c7<\/p>\n","protected":false},"author":1,"featured_media":1544370,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,20],"tags":[17309,30499,15203,19896,8230,87294],"class_list":["post-1544369","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","category-turkiye","tag-arttiriyor","tag-kalim","tag-losemi","tag-oranini","tag-sag","tag-teknolojide"],"_links":{"self":[{"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/1544369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1544369"}],"version-history":[{"count":0,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/posts\/1544369\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=\/wp\/v2\/media\/1544370"}],"wp:attachment":[{"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1544369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1544369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.erzhaber.com.tr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1544369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}